University of Queensland researchers are seeking volunteers aged 45-70 for a study of osteoarthritis of the knee.
The study is being held by the Joint Injury, Disease and Muscle Function research team led by Dr Joanne Bullock-Saxton of the University's Physiotherapy Department.
Dr Bullock-Saxton said osteoarthritis was a chronic disorder resulting from excessive erosion of the cartilage surface (which helps to cushion the forces acting on the joint).
'There is usually some bone formation at the joint margins and a gradual loss of function due to pain and stiffness,' she said.
'Symptoms of stiffness and pain are often worse in the morning, as it takes a while for the joint to become mobile after rest.'
Dr Bullock-Saxton said cartilage breakdown - particularly in the lower limbs - could occur through direct damage (such as a fracture or ligament rupture). It could also happen over a longer period through uneven distribution of pressure on the joint surface (due to ligament strain/rupture or less than optimal lower limb joint biomechanics).
The University team is continuing investigations into the nature of sensory and muscle function changes due to osteoarthritis of the knee.
Dr Bullock-Saxton said the project aimed to identify changes associated with osteoarthritis, to assess and develop innovative therapeutic treatments.
Volunteers for the trials, which begin at the end of June 1997, would be required to undertake three tests, lasting a total 70 minutes.
People wishing to take part can contact the Joint Injury, Disease and Muscle Function Laboratory (telephone (07) 33654587).
